Synergy between Natriuretic Peptides and Phosphodiesterase 5 Inhibitors Ameliorates Pulmonary Arterial Hypertension

Rationale: Phosphodiesterase 5 (PDE5) inhibitors (e.g., sildenafil) are selective pulmonary vasodilators in patients with pulmonary arterial hypertension. The mechanism(s) underlying this specificity remains unclear, but studies in genetically modified animals suggest it might be dependent on natriu...

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Detalhes bibliográficos
Main Authors: Baliga, Reshma S., Zhao, Lan, Madhani, Melanie, Lopez-Torondel, Belen, Visintin, Cristina, Selwood, David, Wilkins, Martin R., MacAllister, Raymond J., Hobbs, Adrian J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Thoracic Society 2008
Assuntos:
H. Pulmonary Vascular Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643218/
https://ncbi.nlm.nih.gov/pubmed/18689467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200801-121OC
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