Synergy between Natriuretic Peptides and Phosphodiesterase 5 Inhibitors Ameliorates Pulmonary Arterial Hypertension

Rationale: Phosphodiesterase 5 (PDE5) inhibitors (e.g., sildenafil) are selective pulmonary vasodilators in patients with pulmonary arterial hypertension. The mechanism(s) underlying this specificity remains unclear, but studies in genetically modified animals suggest it might be dependent on natriu...

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Main Authors: Baliga, Reshma S., Zhao, Lan, Madhani, Melanie, Lopez-Torondel, Belen, Visintin, Cristina, Selwood, David, Wilkins, Martin R., MacAllister, Raymond J., Hobbs, Adrian J.
Format: Artigo
Sprog:Inglês
Udgivet: American Thoracic Society 2008
Fag:
H. Pulmonary Vascular Disease
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643218/
https://ncbi.nlm.nih.gov/pubmed/18689467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200801-121OC
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