Synergy between Natriuretic Peptides and Phosphodiesterase 5 Inhibitors Ameliorates Pulmonary Arterial Hypertension

Rationale: Phosphodiesterase 5 (PDE5) inhibitors (e.g., sildenafil) are selective pulmonary vasodilators in patients with pulmonary arterial hypertension. The mechanism(s) underlying this specificity remains unclear, but studies in genetically modified animals suggest it might be dependent on natriu...

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Autores principales: Baliga, Reshma S., Zhao, Lan, Madhani, Melanie, Lopez-Torondel, Belen, Visintin, Cristina, Selwood, David, Wilkins, Martin R., MacAllister, Raymond J., Hobbs, Adrian J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Thoracic Society 2008
Materias:
H. Pulmonary Vascular Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643218/
https://ncbi.nlm.nih.gov/pubmed/18689467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.200801-121OC
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