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Isoform-Specific Functions of Phosphoinositide 3-Kinases: p110δ but Not p110γ Promotes Optimal Allergic Responses In Vivo

The leukocyte-enriched p110γ and p110δ isoforms of PI3K have been shown to control in vitro degranulation of mast cells induced by cross-linking of the high affinity receptor of IgE (FcεRI). However, the relative contribution of these PI3K isoforms in IgE-dependent allergic responses in vivo is cont...

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Autores principales: Ali, Khaled, Camps, Montserrat, Pearce, Wayne P., Ji, Hong, Rückle, Thomas, Kuehn, Nicolas, Pasquali, Christian, Chabert, Christian, Rommel, Christian, Vanhaesebroeck, Bart
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2643005/
https://ncbi.nlm.nih.gov/pubmed/18250464
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