Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

Clinical trials of small interfering RNA (siRNA) targeting vascular endothelial growth factor-A (VEGFA) or its receptor VEGFR1 (also called FLT1), in patients with blinding choroidal neovascularization (CNV) from age-related macular degeneration, are premised on gene silencing by means of intracellu...

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Autors principals: Kleinman, Mark E., Yamada, Kiyoshi, Takeda, Atsunobu, Chandrasekaran, Vasu, Nozaki, Miho, Baffi, Judit Z., Albuquerque, Romulo J. C., Yamasaki, Satoshi, Itaya, Masahiro, Pan, Yuzhen, Appukuttan, Binoy, Gibbs, Daniel, Yang, Zhenglin, Karikó, Katalin, Ambati, Balamurali K., Wilgus, Traci A., DiPietro, Luisa A., Sakurai, Eiji, Zhang, Kang, Smith, Justine R., Taylor, Ethan W., Ambati, Jayakrishna
Format: Artigo
Idioma:Inglês
Publicat: 2008
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2642938/
https://ncbi.nlm.nih.gov/pubmed/18368052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature06765
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