Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

Clinical trials of small interfering RNA (siRNA) targeting vascular endothelial growth factor-A (VEGFA) or its receptor VEGFR1 (also called FLT1), in patients with blinding choroidal neovascularization (CNV) from age-related macular degeneration, are premised on gene silencing by means of intracellu...

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Detalhes bibliográficos
Main Authors: Kleinman, Mark E., Yamada, Kiyoshi, Takeda, Atsunobu, Chandrasekaran, Vasu, Nozaki, Miho, Baffi, Judit Z., Albuquerque, Romulo J. C., Yamasaki, Satoshi, Itaya, Masahiro, Pan, Yuzhen, Appukuttan, Binoy, Gibbs, Daniel, Yang, Zhenglin, Karikó, Katalin, Ambati, Balamurali K., Wilgus, Traci A., DiPietro, Luisa A., Sakurai, Eiji, Zhang, Kang, Smith, Justine R., Taylor, Ethan W., Ambati, Jayakrishna
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2642938/
https://ncbi.nlm.nih.gov/pubmed/18368052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature06765
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