Sequence- and target-independent angiogenesis suppression by siRNA via TLR3

Clinical trials of small interfering RNA (siRNA) targeting vascular endothelial growth factor-A (VEGFA) or its receptor VEGFR1 (also called FLT1), in patients with blinding choroidal neovascularization (CNV) from age-related macular degeneration, are premised on gene silencing by means of intracellu...

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Библиографические подробности
Главные авторы: Kleinman, Mark E., Yamada, Kiyoshi, Takeda, Atsunobu, Chandrasekaran, Vasu, Nozaki, Miho, Baffi, Judit Z., Albuquerque, Romulo J. C., Yamasaki, Satoshi, Itaya, Masahiro, Pan, Yuzhen, Appukuttan, Binoy, Gibbs, Daniel, Yang, Zhenglin, Karikó, Katalin, Ambati, Balamurali K., Wilgus, Traci A., DiPietro, Luisa A., Sakurai, Eiji, Zhang, Kang, Smith, Justine R., Taylor, Ethan W., Ambati, Jayakrishna
Формат: Artigo
Язык:Inglês
Опубликовано: 2008
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2642938/
https://ncbi.nlm.nih.gov/pubmed/18368052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature06765
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