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Autophagy Provides Nutrients but Can Lead to Chop-dependent Induction of Bim to Sensitize Growth Factor–deprived Cells to Apoptosis

Tissue homeostasis is controlled by the availability of growth factors, which sustain exogenous nutrient uptake and prevent apoptosis. Although autophagy can provide an alternate intracellular nutrient source to support essential basal metabolism of apoptosis-resistant growth factor–withdrawn cells,...

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Autori principali: Altman, Brian J., Wofford, Jessica A., Zhao, Yuxing, Coloff, Jonathan L., Ferguson, Emily C., Wieman, Heather L., Day, Amanda E., Ilkayeva, Olga, Rathmell, Jeffrey C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The American Society for Cell Biology 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2642748/
https://ncbi.nlm.nih.gov/pubmed/19109422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E08-08-0829
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