Glycogen Synthase Kinase 3α and 3β Mediate a Glucose-Sensitive Antiapoptotic Signaling Pathway To Stabilize Mcl-1

Glucose uptake and utilization are growth factor-stimulated processes that are frequently upregulated in cancer cells and that correlate with enhanced cell survival. The mechanism of metabolic protection from apoptosis, however, has been unclear. Here we identify a novel signaling pathway initiated...

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Main Authors: Zhao, Yuxing, Altman, Brian J., Coloff, Jonathan L., Herman, Catherine E., Jacobs, Sarah R., Wieman, Heather L., Wofford, Jessica A., Dimascio, Leah N., Ilkayeva, Olga, Kelekar, Ameeta, Reya, Tannishtha, Rathmell, Jeffrey C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2007
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1900055/
https://ncbi.nlm.nih.gov/pubmed/17371841
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00153-07
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