Enhanced selection of FoxP3(+) T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease

It is generally acknowledged that cytotoxic T-lymphocyte–associated antigen-4 (CTLA-4/CD152) plays a pivotal role in the regulation of T-cell activation and the establishment of self-tolerance in the periphery. CTLA-4–deficient (CTLA-4KO) mice develop a lymphoproliferative disorder and die within 4...

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Main Authors: Verhagen, Johan, Gabryšová, Leona, Minaee, Sophie, Sabatos, Catherine A., Anderson, Graham, Sharpe, Arlene H., Wraith, David C.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2009
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2642665/
https://ncbi.nlm.nih.gov/pubmed/19218450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803186106
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