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Enhanced selection of FoxP3(+) T-regulatory cells protects CTLA-4-deficient mice from CNS autoimmune disease
It is generally acknowledged that cytotoxic T-lymphocyte–associated antigen-4 (CTLA-4/CD152) plays a pivotal role in the regulation of T-cell activation and the establishment of self-tolerance in the periphery. CTLA-4–deficient (CTLA-4KO) mice develop a lymphoproliferative disorder and die within 4...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2642665/ https://ncbi.nlm.nih.gov/pubmed/19218450 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803186106 |
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