Recombinant scrapie-like prion protein of 106 amino acids is soluble

The N terminus of the scrapie isoform of prion protein (PrP(Sc)) can be truncated without loss of scrapie infectivity and, correspondingly, the truncation of the N terminus of the cellular isoform, PrP(C), still permits conversion into PrP(Sc). To assess whether additional segments of the PrP molecu...

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Bibliographic Details
Main Authors: Muramoto, Tamaki, Scott, Michael, Cohen, Fred E., Prusiner, Stanley B.
Format: Artigo
Language:Inglês
Published: The National Academy of Sciences of the USA 1996
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC26426/
https://ncbi.nlm.nih.gov/pubmed/8986833
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