Upregulation of prolylcarboxypeptidase (PRCP) in lipopolysaccharide (LPS) treated endothelium promotes inflammation

BACKGROUND: Prolylcarboxypeptidase (Prcp) gene, along with altered PRCP and kallikrein levels, have been implicated in inflammation pathogenesis. PRCP regulates angiotensin 1–7 (Ang 1–7) – and bradykinin (BK) – stimulated nitric oxide production in endothelial cells. The mechanism through which kall...

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Autors principals: Ngo, My-Linh, Mahdi, Fakhri, Kolte, Dhaval, Shariat-Madar, Zia
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2009
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2639534/
https://ncbi.nlm.nih.gov/pubmed/19171072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-9255-6-3
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