Over-expression of a modified bifunctional apoptosis regulator protects against cardiac injury and doxorubicin-induced cardiotoxicity in transgenic mice

AIMS: Bifunctional apoptosis regulator (BAR) is an endoplasmic reticulum protein that interacts with both the extrinsic and intrinsic apoptosis pathways. We hypothesize that over-expression of BARΔRING prevents apoptosis and injury following ischaemia/reperfusion (I/R) and attenuates doxorubicin (DO...

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Detalhes bibliográficos
Main Authors: Chua, Chu Chang, Gao, Jinping, Ho, Ye-Shih, Xu, Xingshun, Kuo, I-Chun, Chua, Kaw-Yan, Wang, Hong, Hamdy, Ronald C., Reed, John C., Chua, Balvin H.L.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2009
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Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2639090/
https://ncbi.nlm.nih.gov/pubmed/18805781
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvn257
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