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Glutathione peroxidase 1-deficient mice are more susceptible to doxorubicin-induced cardiotoxicity
Doxorubicin (DOX)-induced cardiotoxicity is thought to be mediated by the generation of superoxide anion radicals (superoxide) from redox cycling of DOX in cardiomyocyte mitochondria. Reduction of superoxide generates H(2)O(2), which diffuses throughout the cell and potentially contributes to oxidan...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2629733/ https://ncbi.nlm.nih.gov/pubmed/18602426 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2008.05.027 |
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