Overexpression of IAP-2 attenuates apoptosis and protects against myocardial ischemia/reperfusion injury in transgenic mice

Inhibitors of apoptosis proteins (IAPs) are key intrinsic regulators of caspases-3 and -7. During ischemia, IAP-2 is upregulated dramatically, while the other IAPs show little or no change. To test whether IAP-2 prevents cardiac apoptosis and injury following ischemia/reperfusion, we generated a lin...

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Bibliografiske detaljer
Main Authors: Chua, Chu Chang, Gao, Jinping, Ho, Ye-Shih, Xiong, Ye, Xu, Xingshun, Chen, Zhongyi, Hamdy, Ronald C., Chua, Balvin H.L.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2709410/
https://ncbi.nlm.nih.gov/pubmed/17321613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbamcr.2007.01.007
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