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Roles of Coactivator Proteins in Dioxin Induction of CYP1A1 and CYP1B1 in Human Breast Cancer Cells

Cytochrome P450 (CYP) 1A1 and CYP1B1 are inducible by 2,3,7,8-tetrachlorodibenzo-p-dioxin (dioxin) in the human breast cancer cell line, MCF-7. Since CYP1A1 was inducible to a much greater degree than CYP1B1, we hypothesized that there may be differences in coactivator recruitment to the promoter an...

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Bibliografiske detaljer
Main Authors: Taylor, Robert T., Wang, Feng, Hsu, Erin L., Hankinson, Oliver
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2638648/
https://ncbi.nlm.nih.gov/pubmed/18842620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfn217
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