Mechanism of action of a repressor of dioxin-dependent induction of Cyp1a1 gene transcription.

A dominant mutant of Hepa-1 cells, c31, expresses a repressor that prevents 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)-dependent stimulation of Cyp1a1 transcription. The repressor acts via the xenobiotic-responsive elements (XREs), which are the DNA-binding sites for the aryl hydrocarbon (Ah) recept...

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Detalhes bibliográficos
Main Authors: Watson, A J, Weir-Brown, K I, Bannister, R M, Chu, F F, Reisz-Porszasz, S, Fujii-Kuriyama, Y, Sogawa, K, Hankinson, O
Formato: Artigo
Idioma:Inglês
Publicado em: 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC364383/
https://ncbi.nlm.nih.gov/pubmed/1314949
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