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Transactivation domains facilitate promoter occupancy for the dioxin-inducible CYP1A1 gene in vivo.

We have studied the transcriptional regulation of the dioxin-inducible mouse CYP1A1 gene in its native chromosomal setting. We analyzed the ability of aromatic hydrocarbon receptor (AhR) mutants and AhR chimeras to restore dioxin responsiveness to the CYP1A1 gene in AhR-defective mouse hepatoma cell...

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Autors principals: Ko, H P, Okino, S T, Ma, Q, Whitlock, J P
Format: Artigo
Idioma:Inglês
Publicat: 1997
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC232203/
https://ncbi.nlm.nih.gov/pubmed/9199285
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