Histone deacetylase inhibitors upregulate Notch1 and inhibit growth in pheochromocytoma cells

BACKGROUND: The histone deacetylase (HDAC) inhibitors valproic acid (VPA) and suberoyl bis-hydroxamic acid (SBHA) have recently been demonstrated to be strong Notch1 activators. Upregulation of the Notch1 pathway has been shown to limit growth and suppress hormonal secretion in neuroendocrine (NE) t...

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Bibliographic Details
Main Authors: Adler, Joel T., Hottinger, Daniel G., Kunnimalaiyaan, Muthusamy, Chen, Herbert
Format: Artigo
Language:Inglês
Published: 2008
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2638099/
https://ncbi.nlm.nih.gov/pubmed/19041003
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.surg.2008.08.027
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