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Combination therapy with histone deacetylase inhibitors and lithium chloride: a novel treatment for carcinoid tumors
BACKGROUND: In carcinoid cell lines, the histone deacetylase (HDAC) inhibitors valproic acid (VPA) and suberoyl bis-hydroxamic acid (SBHA) activate the Notch1 pathway, while lithium inhibits glycogen synthase kinase-3β (GSK-3β). These compounds limit growth and decrease hormonal secretion in vitro....
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2740795/ https://ncbi.nlm.nih.gov/pubmed/19030935 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1245/s10434-008-0194-6 |
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