High-Level Production of Amorpha-4,11-Diene, a Precursor of the Antimalarial Agent Artemisinin, in Escherichia coli

BACKGROUND: Artemisinin derivatives are the key active ingredients in Artemisinin combination therapies (ACTs), the most effective therapies available for treatment of malaria. Because the raw material is extracted from plants with long growing seasons, artemisinin is often in short supply, and ferm...

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Bibliografiske detaljer
Main Authors: Tsuruta, Hiroko, Paddon, Christopher J., Eng, Diana, Lenihan, Jacob R., Horning, Tizita, Anthony, Larry C., Regentin, Rika, Keasling, Jay D., Renninger, Neil S., Newman, Jack D.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2009
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2637983/
https://ncbi.nlm.nih.gov/pubmed/19221601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0004489
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