Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin

Malaria, caused by Plasmodium sp, results in almost one million deaths and over 200 million new infections annually. The World Health Organization has recommended that artemisinin-based combination therapies be used for treatment of malaria. Artemisinin is a sesquiterpene lactone isolated from the p...

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Detalhes bibliográficos
Main Authors: Westfall, Patrick J., Pitera, Douglas J., Lenihan, Jacob R., Eng, Diana, Woolard, Frank X., Regentin, Rika, Horning, Tizita, Tsuruta, Hiroko, Melis, David J., Owens, Andrew, Fickes, Scott, Diola, Don, Benjamin, Kirsten R., Keasling, Jay D., Leavell, Michael D., McPhee, Derek J., Renninger, Neil S., Newman, Jack D., Paddon, Chris J.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3271868/
https://ncbi.nlm.nih.gov/pubmed/22247290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1110740109
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