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Synthesis of amorpha-4,11-diene from dihydroartemisinic acid
Amorphadiene is a natural product involved in the biosynthesis of the antimalarial drug artemisinin. A convenient four-step synthesis of amorphadiene, starting from commercially available dihydroartemisinic acid, is reported. The targeted molecule is isolated with an overall yield of 85% on a multi-...
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| Publicado no: | Tetrahedron |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Pergamon Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6346372/ https://ncbi.nlm.nih.gov/pubmed/30739959 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tet.2018.12.050 |
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