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An Antiviral Response Directed by PKR Phosphorylation of the RNA Helicase A
The double-stranded RNA-activated protein kinase R (PKR) is a key regulator of the innate immune response. Activation of PKR during viral infection culminates in phosphorylation of the α subunit of the eukaryotic translation initiation factor 2 (eIF2α) to inhibit protein translation. A broad range o...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2637979/ https://ncbi.nlm.nih.gov/pubmed/19229320 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000311 |
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