Human DICER helicase domain recruits PKR and modulates its antiviral activity

The antiviral innate immune response mainly involves type I interferon (IFN) in mammalian cells. The contribution of the RNA silencing machinery remains to be established, but several recent studies indicate that the ribonuclease DICER can generate viral siRNAs in specific conditions. It has also be...

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發表在:PLoS Pathog
Main Authors: Montavon, Thomas C., Baldaccini, Morgane, Lefèvre, Mathieu, Girardi, Erika, Chane-Woon-Ming, Béatrice, Messmer, Mélanie, Hammann, Philippe, Chicher, Johana, Pfeffer, Sébastien
格式: Artigo
語言:Inglês
出版: Public Library of Science 2021
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC8118307/
https://ncbi.nlm.nih.gov/pubmed/33984068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1009549
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