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Increased Expression of the Akt/PKB Inhibitor TRB3 in Osteoarthritic Chondrocytes Inhibits IGF-1 Mediated Cell Survival and Proteoglycan Synthesis
OBJECTIVE: The chondrocyte response to IGF-1 is reduced with aging and in OA. IGF-1 signals through the PI-3 kinase/Akt pathway. TRB3, a tribbles homolog, has been shown to inhibit IGF-1 activation of Akt in HEK293 cells. In this study, we determined if TRB3 is expressed in chondrocytes and if TRB3...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2637941/ https://ncbi.nlm.nih.gov/pubmed/19180501 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.24225 |
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