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IGF-I stimulation of proteoglycan synthesis by chondrocytes requires activation of the PI 3-kinase pathway but not ERK MAPK

The IGF-I (insulin-like growth factor-I) signalling pathway responsible for regulation of proteoglycan synthesis in chondrocytes has not been defined and is the focus of the present study. Chondrocytes isolated from normal human articular cartilage were stimulated with IGF-I in monolayer culture or...

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Detalhes bibliográficos
Main Authors: Starkman, Bela G., Cravero, John D., DelCarlo, Marcello, Loeser, Richard F.
Formato: Artigo
Idioma:Inglês
Publicado em: Portland Press Ltd. 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1180722/
https://ncbi.nlm.nih.gov/pubmed/15801908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20041636
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