The ribosomal stalk is required for ribosome binding, depurination of the rRNA and cytotoxicity of ricin A chain in Saccharomyces cerevisiae

Ribosome inactivating proteins (RIPs) like ricin, pokeweed antiviral protein (PAP) and Shiga-like toxins 1 and 2 (Stx1 and Stx2) share the same substrate, the α-sarcin/ricin loop, but differ in their specificities towards prokaryotic and eukaryotic ribosomes. Ricin depurinates the eukaryotic ribosom...

Full description

Saved in:
Bibliographic Details
Main Authors: Chiou, Jia-Chi, Li, Xiao-Ping, Remacha, Miguel, Ballesta, Juan P. G., Tumer, Nilgun E.
Format: Artigo
Language:Inglês
Published: 2008
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2637795/
https://ncbi.nlm.nih.gov/pubmed/19019145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2958.2008.06492.x
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items