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Identification of Chemical Inhibitors to Human Tissue Transglutaminase by Screening Existing Drug Libraries
Human tissue transglutaminase (TGM2) is a calcium-dependent crosslinking enzyme involved in the post-translational modification of intra- and extra-cellular proteins and involved in several neurodegenerative diseases. To find specific inhibitors to TGM2, two structurally diverse chemical libraries (...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2008
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2637080/ https://ncbi.nlm.nih.gov/pubmed/18804034 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2008.07.015 |
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