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Modifying Culture Conditions in Chemical Library Screening Identifies Alternative Inhibitors of Mycobacteria

In this study, application of a dual absorbance/fluorescence assay to a chemical library screen identified several previously unknown inhibitors of mycobacteria. In addition, growth conditions had a significant effect on the activity profile of the library. Some inhibitors such as Se-methylselenocys...

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Main Authors: Miller, Christopher H., Nisa, Shahista, Dempsey, Sandi, Jack, Cameron, O'Toole, Ronan
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786345/
https://ncbi.nlm.nih.gov/pubmed/19786608
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00803-09
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