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Mimicking phosphorylation of Ser-74 on human deoxycytidine kinase selectively increases catalytic activity for dC and dC analogues

Intracellular phosphorylation of dCK on Ser-74 results in increased nucleoside kinase activity. We mimicked this phosphorylation by a Ser-74-Glu mutation in bacterially produced dCK and investigated kinetic parameters using various nucleoside substrates. The S74E mutation increases the k(cat) values...

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Autores principales: McSorley, Theresa, Ort, Stephan, Hazra, Saugata, Lavie, Arnon, Konrad, Manfred
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2636680/
https://ncbi.nlm.nih.gov/pubmed/18258203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2008.01.048
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