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Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4

Temperature-activated transient receptor potential ion channels (thermoTRPs) are polymodal detectors of various stimuli including temperature, voltage, and chemicals. To date, it is not known how TRP channels integrate the action of such disparate stimuli. Identifying specific residues required for...

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Detalhes bibliográficos
Main Authors: Hu, Hongzhen, Grandl, Jörg, Bandell, Michael, Petrus, Matt, Patapoutian, Ardem
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2635798/
https://ncbi.nlm.nih.gov/pubmed/19164517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812209106
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