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Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4

Temperature-activated transient receptor potential ion channels (thermoTRPs) are polymodal detectors of various stimuli including temperature, voltage, and chemicals. To date, it is not known how TRP channels integrate the action of such disparate stimuli. Identifying specific residues required for...

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Détails bibliographiques
Auteurs principaux: Hu, Hongzhen, Grandl, Jörg, Bandell, Michael, Petrus, Matt, Patapoutian, Ardem
Format: Artigo
Langue:Inglês
Publié: National Academy of Sciences 2009
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2635798/
https://ncbi.nlm.nih.gov/pubmed/19164517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0812209106
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