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Epigenetic restriction of embryonic cell lineage fate by methylation of Elf5
Mouse ES cells can differentiate into all three germ layers of the embryo but are generally excluded from the trophoblast lineage. Here we show that ES cells deficient in DNA methylation can differentiate efficiently into trophoblast derivatives. In a genome-wide screen we identify the transcription...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2008
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2635539/ https://ncbi.nlm.nih.gov/pubmed/18836439 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1786 |
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