Epigenetic restriction of embryonic cell lineage fate by methylation of Elf5

Mouse ES cells can differentiate into all three germ layers of the embryo but are generally excluded from the trophoblast lineage. Here we show that ES cells deficient in DNA methylation can differentiate efficiently into trophoblast derivatives. In a genome-wide screen we identify the transcription...

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Bibliografiske detaljer
Main Authors:	Ng, Ray Kit, Dean, Wendy, Dawson, Claire, Lucifero, Diana, Madeja, Zofia, Reik, Wolf, Hemberger, Myriam
Format:	Artigo
Sprog:	Inglês
Udgivet:	2008
Fag:	Article
Online adgang:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2635539/ https://ncbi.nlm.nih.gov/pubmed/18836439 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncb1786
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Epigenetic restriction of embryonic cell lineage fate by methylation of Elf5

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