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Kinetic and structural analysis of mutant CD4 receptors that are defective in HIV gp120 binding

The T-cell antigen coreceptor CD4 also serves as the receptor for the envelope glycoprotein gp120 of HIV. Extensive mutational analysis of CD4 has implicated residues from a portion of the extracellular amino-terminal domain (D1) in gp120 binding. However, none of these proteins has been fully chara...

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Sparad:
I publikationen:Proc Natl Acad Sci U S A
Huvudupphov: Wu, Hao, Myszka, David G., Tendian, Susan W., Brouillette, Christie G., Sweet, Ray W., Chaiken, Irwin M., Hendrickson, Wayne A.
Materialtyp: Artigo
Språk:Inglês
Utgiven: National Academy of Sciences 1996
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC26350/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8986758/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.26.15030
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