Evidence for penetration of diphtheria toxin to the cytosol through a prelysosomal membrane.
To kill mammalian cells, diphtheria toxin must be endocytosed and encounter a low pH within intracellular vesicles. The low pH initiates penetration of the catalytically active A fragment of the toxin through a membrane and into the cytosol where the A fragment arrests protein synthesis. To investig...
Guardat en:
| Publicat a: | Infect Immun |
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| Autors principals: | , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology (ASM)
1984
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC263484/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6706404/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.44.1.145-150.1984 |
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