pH-Triggered Conformational Switching along the Membrane Insertion Pathway of the Diphtheria Toxin T-Domain

The translocation (T)-domain plays a key role in the action of diphtheria toxin and is responsible for transferring the catalytic domain across the endosomal membrane into the cytosol in response to acidification. Deciphering the molecular mechanism of pH-dependent refolding and membrane insertion o...

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Autor principal:	Alexey S. Ladokhin
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2013-08-01
coleção:	Toxins
Assuntos:	acid-induced conformational change membrane protein insertion histidine protonation fluorescence molecular dynamics conformational switch
Acesso em linha:	http://www.mdpi.com/2072-6651/5/8/1362
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