Evidence for penetration of diphtheria toxin to the cytosol through a prelysosomal membrane.

To kill mammalian cells, diphtheria toxin must be endocytosed and encounter a low pH within intracellular vesicles. The low pH initiates penetration of the catalytically active A fragment of the toxin through a membrane and into the cytosol where the A fragment arrests protein synthesis. To investig...

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Veröffentlicht in:	Infect Immun
Hauptverfasser:	Marnell, M H, Shia, S P, Stookey, M, Draper, R K
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 1984
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC263484/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6706404/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.44.1.145-150.1984
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