Improving Tumor-Targeting Capability and Pharmacokinetics of (99m)Tc-Labeled Cyclic RGD Dimers with PEG(4) Linkers

This report describes the synthesis of two cyclic RGD (Arg-Gly-Asp) conjugates, HYNIC-2PEG(4)-dimer (HYNIC = 6-hydrazinonicotinyl; 2PEG(4)-dimer = E[PEG(4)-c(RGDfK)](2); and PEG(4) = 15-amino-4,7,10,13-tetraoxapentadecanoic acid) and HYNIC-3PEG(4)-dimer (3PEG(4)-dimer = PEG(4)-E[PEG(4)-c(RGDfK)](2))...

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Dettagli Bibliografici
Autori principali: Wang, Lijun, Shi, Jiyun, Kim, Young-Seung, Zhai, Shizhen, Jia, Bing, Zhao, Huiyun, Liu, Zhaofei, Wang, Fan, Chen, Xiaoyuan, Liu, Shuang
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2634825/
https://ncbi.nlm.nih.gov/pubmed/19067525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/mp800150r
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