Improving Tumor Uptake and Excretion Kinetics of (99m)Tc-Labeled Cyclic Arginine-Glycine-Aspartic (RGD) Dimers with Triglycine Linkers

This report describes the synthesis of two new cyclic RGD (Arg-Gly-Asp) dimers, 3 (E[G(3)-c(RGDfK)](2)) and 4 (G(3)-E[G(3)-c(RGDfK)](2)), and their corresponding conjugates 5 (HYNIC-E[G(3)-c(RGDfK)](2): HYNIC = 6-(2-(2-sulfonatobenzaldehyde)hydrazono)nicotinyl) and 6 (HYNIC-G(3)-E[G(3)-c(RGDfK)](2))...

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Main Authors: Shi, Jiyun, Wang, Lijun, Kim, Young-Seung, Zhai, Shizhen, Liu, Zhaofei, Chen, Xiaoyuan, Liu, Shuang
Formato: Artigo
Idioma:Inglês
Publicado: 2008
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2626178/
https://ncbi.nlm.nih.gov/pubmed/19049428
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm801134k
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