LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model

Persistent activation of the signal transducer and activator of transcription 3 (STAT3) signalling has been linked to oncogenesis and the development of chemotherapy resistance in glioblastoma and other cancers. Inhibition of the STAT3 pathway thus represents an attractive therapeutic approach for c...

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Detalhes bibliográficos
Main Authors: Fuh, B, Sobo, M, Cen, L, Josiah, D, Hutzen, B, Cisek, K, Bhasin, D, Regan, N, Lin, L, Chan, C, Caldas, H, DeAngelis, S, Li, C, Li, P-K, Lin, J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
Assuntos:
Translational Therapeutics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2634692/
https://ncbi.nlm.nih.gov/pubmed/19127268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6604793
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