Anti-bovine prion protein RNA aptamer containing tandem GGA repeat interacts both with recombinant bovine prion protein and its β isoform with high affinity

In order to obtain RNA aptamers against bovine prion protein (bPrP), we carried out in vitro selection from RNA pools containing a 55-nucleotide randomized region to target recombinant bPrP. Most of obtained aptamers contained conserved GGA tandem repeats (GGA)(4) and aptamer #1 (apt #1) showed a hi...

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Autores principales: Murakami, Kazuyoshi, Nishikawa, Fumiko, Noda, Ken, Yokoyama, Takashi, Nishikawa, Satoshi
Formato: Artigo
Lenguaje:Inglês
Publicado: Landes Bioscience 2008
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Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2634522/
https://ncbi.nlm.nih.gov/pubmed/19098441
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