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Accumulation of Rhodopsin in Late Endosomes Triggers Photoreceptor Cell Degeneration

Progressive retinal degeneration is the underlying feature of many human retinal dystrophies. Previous work using Drosophila as a model system and analysis of specific mutations in human rhodopsin have uncovered a connection between rhodopsin endocytosis and retinal degeneration. In these mutants, r...

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Bibliografske podrobnosti
Main Authors: Chinchore, Yashodhan, Mitra, Amitavo, Dolph, Patrick J.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2633617/
https://ncbi.nlm.nih.gov/pubmed/19214218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1000377
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