Novel Dominant Rhodopsin Mutation Triggers Two Mechanisms of Retinal Degeneration and Photoreceptor Desensitization

A variety of rod opsin mutations result in autosomal dominant retinitis pigmentosa and congenital night blindness in humans. One subset of these mutations encodes constitutively active forms of the rod opsin protein. Some of these dominant rod opsin mutant proteins, which desensitize transgenic Xeno...

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Bibliographic Details
Published in:J Neurosci
Main Authors: Iakhine, Roustem, Chorna-Ornan, Irit, Zars, Troy, Elia, Natalie, Cheng, Yan, Selinger, Zvi, Minke, Baruch, Hyde, David R.
Format: Artigo
Language:Inglês
Published: Society for Neuroscience 2004
Subjects:
Neurobiology of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6729501/
https://ncbi.nlm.nih.gov/pubmed/15014127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5426-03.2004
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