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Characterization of Novel Forms of Coagulation Factor XIa: INDEPENDENCE OF FACTOR XIa SUBUNITS IN FACTOR IX ACTIVATION

Factor XI is the zymogen of a dimeric plasma protease, factor XIa, with two active sites. In solution, and during contact activation in plasma, conversion of factor XI to factor XIa proceeds through an intermediate with one active site (1/2-FXIa). Factor XIa and 1/2-FXIa activate the substrate facto...

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Hlavní autoři: Smith, Stephen B., Verhamme, Ingrid M., Sun, Mao-fu, Bock, Paul E., Gailani, David
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2633474/
https://ncbi.nlm.nih.gov/pubmed/18192270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M707234200
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