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Species-Dependent Ensembles of Conserved Conformational States Define the Hsp90 Chaperone ATPase Cycle
SUMMARY: The molecular chaperone Heat Shock Protein 90 (Hsp90) is required for the folding and activation of numerous essential signaling proteins. Hsp90 is generally thought to transition between an open, apo and a closed, ‘ATP’ conformation in response to nucleotide. Here, 3D single particle recon...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2633443/ https://ncbi.nlm.nih.gov/pubmed/19061638 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.10.024 |
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