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Species-Dependent Ensembles of Conserved Conformational States Define the Hsp90 Chaperone ATPase Cycle

SUMMARY: The molecular chaperone Heat Shock Protein 90 (Hsp90) is required for the folding and activation of numerous essential signaling proteins. Hsp90 is generally thought to transition between an open, apo and a closed, ‘ATP’ conformation in response to nucleotide. Here, 3D single particle recon...

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Autori principali: Southworth, Daniel R., Agard, David A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2633443/
https://ncbi.nlm.nih.gov/pubmed/19061638
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.10.024
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