The CUL7 E3 Ubiquitin Ligase Targets Insulin Receptor Substrate 1 for Ubiquitin-Dependent Degradation

Recent genetic studies have documented a pivotal growth-regulatory role played by the Cullin 7 (CUL7) E3 ubiquitin ligase complex containing the Fbw8-substrate-targeting subunit, Skp1, and the ROC1 RING finger protein. In this report, we identified insulin receptor substrate 1 (IRS-1), a critical me...

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Autores principales: Xu, Xinsong, Sarikas, Antonio, Dias-Santagata, Dora C., Dolios, Georgia, Lafontant, Pascal J., Tsai, Shih-Chong, Zhu, Wuqiang, Nakajima, Hidehiro, Nakajima, Hisako O., Field, Loren J., Wang, Rong, Pan, Zhen-Qiang
Formato: Artigo
Lenguaje:Inglês
Publicado: 2008
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2633441/
https://ncbi.nlm.nih.gov/pubmed/18498745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2008.03.009
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