Increased resistance to CD4(+)CD25(hi) regulatory T cell-mediated suppression in patients with type 1 diabetes

Type I diabetes (T1D) is a T cell-mediated autoimmune disease characterized by loss of tolerance to islet autoantigens, leading to the destruction of insulin-producing beta cells. Peripheral tolerance to self is maintained in health through several regulatory mechanisms, including a population of CD...

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Bibliografiske detaljer
Main Authors: Lawson, J M, Tremble, J, Dayan, C, Beyan, H, Leslie, R D G, Peakman, M, Tree, T I M
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2008
Fag:
Translational Studies
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2633239/
https://ncbi.nlm.nih.gov/pubmed/19037920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2008.03810.x
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