Single cell analysis of B lymphocytes from Wegener's granulomatosis: B cell receptors display affinity maturation within the granulomatous lesions

Increased amounts of anti-neutrophil cytoplasm antibody (ANCA) directed against proteinase 3 (PR3) are a diagnostic and pathogenic hallmark of full-blown Wegener's granulomatosis (WG). Aggregates of B lymphocytes proximal to PR3(+) cells as well as plasma cells have been described as substantia...

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Detalhes bibliográficos
Main Authors: Voswinkel, J, Assmann, G, Held, G, Pitann, S, Gross, W L, Holl-Ulrich, K, Herlyn, K, Mueller, A
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2008
Assuntos:
Translational Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2633232/
https://ncbi.nlm.nih.gov/pubmed/18826496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2008.03775.x
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